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Pendulum Therapeutics

San Francisco, California, United Statespendulumlife.com ↗

Ownership: Private
Employees: ~100
Development stage: Commercial

Overview

Pendulum Therapeutics has developed the first clinically proven medical probiotic to lower A1C and blood glucose spikes in people with type 2 diabetes taking metformin. In a double-blind, placebo-controlled trial published in BMJ, their flagship product reduced A1C by an average of 0.6% and post-meal blood glucose spikes by up to one-third. The company’s approach leverages proprietary strains such as live Akkermansia muciniphila to target the GLP‑1 pathway via the gut microbiome. Their products are available both as prescription medical foods for T2D patients and consumer probiotics for broader metabolic support.[4][5][8]

Therapeutic areas: Metabolic DisordersEndocrinologyGastroenterology
Modalities: Probiotics (medical probiotics)Live biotherapeutic products (LBPs)Prebiotic/probiotic blends[1][8]
Industry: Non-Drug Biotech

Drug pipeline

3 assets

Pendulum Glucose Control

Commercial

Indications: Type 2 diabetes

2 more assets in the full pipeline.

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Partnerships

Mayo Clinic (clinical research/registry partner)[4]Fonterra ($10M investment & strategic partnership)[4]

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