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PeriNess completed a Phase 1 trial for DNase I in male infertility and is moving to Phase 2; they are also leading exploratory clinical studies of DNase I in combination with chemotherapy, immunotherapy, and CAR T cell therapy for multiple oncology indications, including pancreatic carcinoma, large B cell lymphoma, and solid tumors. Preclinical and early clinical data suggest efficacy in reducing NETs and improving outcomes when used adjunctively.
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