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Persephone Biosciences

San Diego, California, United Statespersephonebiosciences.com ↗

Ownership: Private
Employees: ~50
Development stage: Phase 1

Overview

Persephone Biosciences has advanced multiple programs into the clinic. Its infant synbiotic product entered the ARTEMIS clinical trial in early 2025 to assess effects on babies' and toddlers' microbiomes. The company’s ARGONAUT study remains one of the largest U.S. efforts mapping the gut–immune axis to identify cancer biomarkers. Early results have enabled collaborations with major pharma partners but no pivotal/late-stage data disclosed yet.[7][10]

Therapeutic areas: GastroenterologyOncologyImmunology
Modalities: Live biotherapeutic products (engineered microbes/probiotics/synbiotics)[4][10]Synbiotics (combination of probiotics and prebiotics)[10]Microbial-based medicines[6]
Industry: Biotech

Drug pipeline

1 asset

HTX-001

Phase 1/2

Indications: Infant health

Partnerships

Janssen Biotech/J&J (colorectal cancer arm collaboration)Ginkgo Bioworks (synthetic biology tools)Kroger Health (“Food as Medicine” AMBROSIA study).[7]

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