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Silverback Therapeutics develops tumor-targeted immunotherapies using its ImmunoTAC platform. Its lead candidate, SBT6050, is a HER2-directed monoclonal antibody conjugated to a TLR8 agonist. Preclinical data show potent anti-tumor immune activity with minimal peripheral toxicity. A first-in-human study in patients with HER2-expressing solid tumors was expected to begin in 2020.
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