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PharmAkea Therapeutics developed small molecule inhibitors targeting key proteins involved in fibrotic diseases and cancer. Its lead asset, PAT‑1251 (a LOXL2 inhibitor), reached Phase II readiness for fibrotic disease and some cancers. Another program targeting autotaxin (PAT‑409) reached Phase I readiness before being sold to Blade Therapeutics. The company merged with Galecto in January 2020; the combined entity continues development under the Galecto name.
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