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Pheast Therapeutics

Palo Alto, CA, United Statespheast.com ↗

Ownership: Private
Employees: ~35
Development stage: Preclinical

Overview

Pheast’s lead asset, PHST001, an anti-CD24 monoclonal antibody designed to block a key macrophage checkpoint, has entered a multicenter Phase 1 clinical trial for advanced solid tumors. Preclinical data showed that PHST001 promoted phagocytosis of cancer cells by macrophages and led to significant tumor shrinkage in animal models. The company’s approach aims to overcome immune evasion by targeting the CD24–Siglec‑10 axis on tumor cells.

Therapeutic areas: Oncology
Modalities: Monoclonal antibodies (mAbs)Macrophage checkpoint inhibitors
Industry: Biotech

Drug pipeline

2 assets

PHST001

1 more asset in the full pipeline.

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