Company intelligence / Profile preview
Phio Pharmaceuticals
Marlborough, Massachusetts, United Statesphiopharma.com ↗
- Ownership
- Public · PHIO
- Employees
- ~5
- Development stage
- Phase 1
01
Overview
Phio’s lead candidate, PH‑762, uses its proprietary INTASYL® self-delivering siRNA platform to silence immune checkpoint genes in tumors. In a Phase 1b trial for advanced skin cancers including cSCC and melanoma, initial results show promising safety and efficacy signals. In the second dose cohort for cSCC patients, two achieved complete response with full tumor clearance at Day 36 post-treatment; one had a partial response (~90% clearance), and another maintained stable disease. The first cohort also showed stable disease outcomes. Dose escalation has been approved by an independent safety committee based on these results.[4]
- Therapeutic areas
- Oncology
- Modalities
- RNA interference (RNAi)siRNA (small interfering RNA)Self-delivering RNAi compounds ("sd-rxRNA")
- Industry
- Biotech
02
Drug pipeline
12 assets11 more assets in the full pipeline.
03
Partnerships
AgonOx Inc., Providence Cancer Institute of Oregon—collaboration on solid tumor immuno-oncology therapies [5].
04
Financials
- Market cap
- $9.3M
- Total revenue
- $0
- Enterprise value
- $-1.3M
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