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Pignus Therapeutics is a pre-clinical stage biotechnology company focused on developing next-generation precision oncology treatments. The company specializes in the discovery and development of isoform-selective inhibitors of phosphoinositide 3-kinase alpha (PI3K alpha), a critical driver in various solid tumors. By leveraging deep expertise in structure-based drug design, Pignus aims to create therapies with improved safety profiles and greater efficacy compared to existing PI3K inhibitors. Their lead programs target specific mutations in the PIK3CA gene, which are prevalent in breast and other cancers.
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