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Pionyr Immunotherapeutics

South San Francisco, California, United Statesprnewswire.com ↗

Ownership: Private
Development stage: Phase 1

Overview

Pionyr’s lead assets PY314 and PY159 are monoclonal antibodies targeting myeloid checkpoints TREM2 and TREM1 respectively. Both completed Phase Ia dose-escalation studies showing safety and tolerability as monotherapy or combined with pembrolizumab. Phase Ib expansion studies were underway for both agents in a range of solid tumor types at the time of acquisition. Early data indicated favorable safety profiles and evidence of immune modulation within the tumor microenvironment.

Therapeutic areas: Oncology
Modalities: Monoclonal antibodies (mAbs)Biologics
Industry: Biotech

Drug pipeline

3 assets

PY159

Phase 1

Indications: Solid tumors

2 more assets in the full pipeline.

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Partnerships

Gilead Sciences held a minority interest with an exclusive option to acquire Pionyr upon completion of certain milestones; strategic collaboration announced July 2020

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