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PolyActiva

Melbourne, Victoria, Australiapolyactiva.com ↗

Ownership: Private
Development stage: Phase 2

Overview

PolyActiva has demonstrated promising interim Phase 2a results with its lead PA5108 Ocular Implant in patients with mild to moderate glaucoma. The implant delivers latanoprost over six months, achieving >20% intraocular pressure reduction at both three and six months. Repeat dosing was shown to be feasible, with no product-related adverse effects reported. In a separate cohort, clinically meaningful IOP reductions of up to ~35% were observed over a total of nearly one year when two implants were administered sequentially. Most patients did not require additional drop therapy during this period.

Therapeutic areas: OphthalmologyInfectious Diseases
Modalities: Small molecules (delivered via polymeric prodrug ocular implants)Biodegradable drug delivery devices/implants
Industry: Biotech

Drug pipeline

4 assets

latanoprost free acid

3 more assets in the full pipeline.

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Partnerships

Venture capital partnerships include Brandon Capital’s Medical Research Commercialisation Fund (MRCF)Yuuwa CapitalBiomedical Translation Fund support from Australian government initiatives.

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