Pono

Pono Therapeutics (also known as Pono Bio) is a San Diego-based biotechnology company focused on the development of precision biologics for oncology. The company utilizes a proprietary discovery platform to identify and target disease-specific protein isoforms and post-translational modifications that are absent in healthy tissues. This approach aims to create highly selective monoclonal antibodies with superior safety profiles and enhanced therapeutic windows compared to conventional therapies. Currently in the pre-clinical stage, Pono is advancing a pipeline of candidates designed to address high-unmet-need solid tumors by targeting previously undruggable or non-selective protein variants. The company's mission is to restore biological balance through isoform-level precision in drug development.