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PrEP Biopharm developed a prophylactic nasal spray drug candidate ("PrEP‑001") designed to stimulate the innate immune system via TLR3 and MDA5 receptors in the nasal mucosa. The product showed preclinical efficacy against multiple respiratory viruses including rhinovirus, MERS, and SARS. Phase I and IIa studies demonstrated safety and proof-of-concept for prevention of viral upper respiratory infections. The company completed toxicology studies enabling further field studies but entered liquidation before advancing to later clinical stages[6].
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