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Primatope developed a high-affinity, non-depleting, non-activating antagonist monoclonal antibody (2C10) targeting CD40, with efficacy established in nonhuman primate immune models and favorable toxicology profile. The lead program (KPL-404, originating from Primatope) was acquired and further developed by Kiniksa Pharmaceuticals in preclinical and early clinical phases[1][4][5].
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