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Principia Biopharma
South San Francisco, California, United Statesprincipiabio.com ↗
- Ownership
- Private
- Employees
- ~14
- Development stage
- Other
01
Overview
Principia developed a pipeline of oral small molecule therapies for immune-mediated diseases, oncology, and CNS conditions. Its lead asset rilzabrutinib was in Phase 3 for pemphigus; PRN2246/SAR442168, a BTK inhibitor crossing the blood-brain barrier, entered multiple Phase 3 trials in MS with Sanofi; PRN473 Topical was in early clinical development. The company’s platform enabled best-in-class candidates with improved safety/selectivity profiles. Clinical results included strong efficacy signals such as an 85% reduction in MRI lesions for MS patients treated with SAR442168 compared to placebo[9].
- Therapeutic areas
- OncologyImmunologyHematologyDermatologyNeurology
- Modalities
- Small molecules (reversible and irreversible covalent inhibitors)
- Industry
- Biotech
02
Partnerships
Sanofi S.A.: Exclusive worldwide license/collaboration on BTK inhibitors including SAR442168/MS program since November 2017; full acquisition completed September–October 2020.[7]Genzyme Corporation/Sanofi Genzyme division collaboration on CNS indications.[4]
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