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ProfoundBio is a clinical-stage biotechnology company focused on developing next-generation antibody-drug conjugates (ADCs) and other antibody-based therapeutics for the treatment of cancer. The company utilizes proprietary linker-payload platforms designed to improve the therapeutic index of ADCs by enhancing stability in circulation and increasing potency within the tumor microenvironment. Its lead candidate, rinatabart sesutecan (PRO1184), is a folate receptor alpha-targeted ADC currently in Phase 2 clinical trials for various solid tumors. In May 2024, ProfoundBio was acquired by Genmab for $1.8 billion to strengthen Genmab's oncology pipeline and ADC capabilities.
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