Pro2FIT

Pro2FIT is a biotechnology company focused on advancing the field of targeted protein degradation (TPD) through the discovery of novel E3 ligase ligands. Spun out from the University of Dundee’s world-leading Centre for Target Protein Degradation (CeTPD), the company utilizes its proprietary Pro2FIT platform to identify small-molecule binders for a diverse range of E3 ligases. This approach aims to overcome the limitations of current TPD efforts, which rely heavily on a small number of ligases like CRBN and VHL. By expanding the available ligase toolkit, Pro2FIT seeks to enable more precise and tissue-specific degradation of disease-causing proteins. The company's technology integrates fragment-based drug discovery, structural biology, and biophysics to accelerate the development of next-generation degraders for oncology and other complex diseases.