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Profluent Bio

Berkeley, California, United Statesprofluent.bio ↗

Ownership: Private
Employees: ~22
Development stage: Preclinical

Overview

Profluent Bio uses advanced deep generative AI models to design novel proteins, including compact gene editors ("OpenCRISPR") and antibodies ("OpenAntibodies"). Their technology has demonstrated the ability to create functional proteins with potential advantages over existing tools like CRISPR-Cas9. The company has made some of its antibody designs available open source or via simple licensing but does not yet have clinical-stage assets. Their work represents a significant advance in the application of AI to biological engineering, with early results showing promise in both efficacy and patentability avoidance.

Therapeutic areas: OtherRare Diseases
Modalities: Protein therapeutics (AI-designed proteins)Gene editors (e.g., OpenCRISPR)Antibodies (OpenAntibodies)
Industry: Biotech

Drug pipeline

1 asset

E1

Preclinical

Partnerships

Notable partnerships are referenced but specific partners are not named in public sources as of May 2025.

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