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Proligo was a prominent global supplier of nucleic acid chemistry products and custom oligonucleotide synthesis services. The company specialized in the production of high-quality phosphoramidites, which are essential building blocks for DNA and RNA synthesis. Proligo was particularly recognized for its expertise in RNA synthesis, supporting the emerging field of RNA interference (RNAi) research during the early 2000s. Following its acquisition by Sigma-Aldrich in 2005, its operations were integrated into Sigma-Aldrich's genomics business. The company's legacy and technologies continue to exist as part of the life science portfolio of Merck KGaA.
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