Company intelligence / Profile preview

Pyxis Oncology

Boston, Massachusetts, United Statesir.pyxisoncology.com ↗
Ownership
Public · PYXS
Employees
~44
Development stage
Other
01

Overview

Pyxis Oncology is a clinical-stage biotech developing next-generation therapeutics for difficult-to-treat cancers. Its lead program, micvotabart pelidotin (“MICVO”, formerly PYX‑201), an ADC targeting EDB+FN in the tumor stroma, is in Phase 1 trials with a focus on recurrent/metastatic HNSCC. The second program, PYX‑106, a Siglec‑15-targeting monoclonal antibody for NSCLC and other solid tumors, is also in Phase 1. A third asset acquired from Apexigen—PYX‑107/sotigalimab—is a CD40 agonist antibody currently under portfolio review after being tested in Phase 2 for melanoma/liposarcoma. Early pipeline programs have been paused or are seeking partners due to strategic reprioritization.

Therapeutic areas
Oncology
Modalities
Antibody-drug conjugateMonoclonal antibodyImmunotherapy (Immuno-oncology)
Industry
Biotech
02

Drug pipeline

11 assets

sotigalimab

2

10 more assets in the full pipeline.

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03

Partnerships

Pfizer (in-license of ADC)Apexigen acquisition brought sotigalimab/PYX–107 into the pipelineLeaps by Bayer led Series A financing round as strategic investor
04

Financials

Market cap
$246.5M
Total revenue
$0
Enterprise value
$231.3M

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