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Refuel Therapeutics is a biotechnology company focused on developing next-generation cell therapies for cancer. The company's platform technology aims to overcome T-cell exhaustion, a major hurdle in the effectiveness of CAR-T and TCR-T therapies, particularly in solid tumors. By "refueling" T-cells through metabolic and epigenetic reprogramming, Refuel seeks to enhance the persistence and potency of immune cells within the immunosuppressive tumor microenvironment. The company was co-founded by renowned immunotherapy expert Dr. Crystal Mackall and is backed by prominent life science investors.
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