Company intelligence / Profile preview

Refuge Biotechnologies

Menlo Park, California, United Statesrefugebiotech.com ↗

Ownership: Private
Employees: ~25
Development stage: Other

Overview

Refuge Biotechnologies was developing intelligent CAR-T cell therapies using a proprietary receptor-dCas platform that leverages CRISPR activation (CRISPRa) and CRISPR interference (CRISPRi) to conditionally regulate gene expression. The company's lead program RB-1916 was a CAR-T therapy designed to inhibit PD-1 expression for diffuse large B-cell lymphoma. In October 2022, Kite (Gilead) entered an exclusive worldwide license agreement for Refuge's platform for blood cancers, while Refuge retained rights for solid tumor indications. The company is now reported as out of business.

Therapeutic areas: HematologyOncology
Modalities: CAR-T cell therapyCell therapyCRISPR-based therapy
Industry: Biotech

Drug pipeline

3 assets

RB-1916

Preclinical

2 more assets in the full pipeline.

Partnerships

Kite: Exclusive worldwide license agreement for Refuge's gene expression platform for blood cancers (October 2022)3SBio: Strategic partner and investor

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