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Reiley Pharmaceuticals is developing a novel diagnostic imaging agent that combines a selective COX‑2 inhibitor with Technetium‑99m to target and illuminate regions of overexpressed COX‑2, enabling precise identification of pain sources such as lower back pain. Their lead candidate, Technetium‑99m-RPI-T‑087, has completed or is undergoing Phase 1 clinical evaluation for safety and tolerability in osteoarthritis of the knee. The company aims to revolutionize precision diagnostics for pain by providing biomarker-based imaging drugs that can pinpoint the biological source of pain[1][3].
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