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Restore Vision has initiated a Phase 1/2 clinical trial for its lead candidate, RV‑001, the world’s first optogenetic "chimeric rhodopsin" gene therapy for retinitis pigmentosa. The first patient was dosed in February 2025. Early results indicate the starting dose is generally well tolerated in this open-label trial. The approach is gene agnostic and aims to restore vision by expanding light sensitivity to retinal interneurons via intravitreal injection of an AAV vector encoding chimeric rhodopsin
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