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RiMO Therapeutics developed a nanotechnology platform using nMOFs to enhance the effect of radiotherapy. Their lead program, RiMO-301, entered Phase 1 trials for head and neck cancer. Preclinical studies indicated the platform could increase tumor response and enhance the benefit of immunotherapy with lower toxicity. As of 2018, RiMO was enrolling patients in clinical trials, but has since been acquired and incorporated into Coordination Pharmaceuticals.[2][3][5][1]
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