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River BioMedics has developed a proprietary human iPSC-derived, three-dimensional cardiac tissue model that enables direct functional assessment of novel drug targets and candidate compounds. Their approach combines GWAS-based target identification with human-relevant functional validation to improve translation into clinical efficacy. The company’s lead program has completed initial target validation and entered the hit-finding phase for small molecule development against heart failure. No clinical results have been reported yet; all programs are preclinical or earlier.
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