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Rogne Bioscience is developing RON-2315, a low–molecular weight human peptide derived from chemerin as a topical biologic for psoriasis; preclinical data showed potent inhibition of dermal inflammation in IL‑23–dependent mouse models and regulation of NF‑kB‑p65 and IL‑23 secretion in human dendritic cells, but the program has since been discontinued with no evidence of advancement into clinical trials.[2][3][5][7]
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