S-Quatre

S-Quatre is a Japanese biotechnology company specializing in the development of advanced lipid nanoparticle (LNP) delivery systems for nucleic acid therapeutics. Founded as a spin-off from Tohoku University and the University of Tokyo, the company utilizes its proprietary 'ssPALM' (SS-cleavable Proton-Activated Lipid-like Materials) technology to create highly efficient and safe delivery vehicles for mRNA and siRNA. This platform features ionizable lipids with disulfide bonds that degrade specifically within the intracellular environment, enhancing endosomal escape and reducing systemic toxicity. S-Quatre provides customized LNP formulations and lipid libraries to pharmaceutical partners to accelerate the development of vaccines and gene therapies. The company is positioned as a key technology provider in the rapidly growing field of genetic medicine.