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S2 Biosciences (also known as S2 Therapeutics) was a specialty pharmaceutical company based in Bristol, Tennessee, focused on the development and commercialization of treatments for metabolic diseases. The company is best known for holding the exclusive global license to Cycloset (bromocriptine mesylate), the first FDA-approved treatment for type 2 diabetes that targets the body's biological clock to improve glycemic control. In 2010, S2 Biosciences and its partner VeroScience entered into a significant distribution and license agreement with Santarus, granting the latter exclusive U.S. rights to manufacture and market Cycloset. The company's leadership included Charles P. Sutphin as President and CEO.
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