Company intelligence / Profile preview
Sangamo Therapeutics
Brisbane, California, United Statessangamo.com ↗
- Ownership
- Public · SGMO
- Employees
- ~354
- Development stage
- Other
01
Overview
Sangamo is a pioneer in genomic medicine using proprietary zinc finger technology platforms. Its lead wholly owned programs target serious neurological and rare genetic diseases. The company has advanced its neurology pipeline toward the clinic and secured major licensing deals with Genentech and Astellas for novel capsid delivery technologies. The Fabry disease program is on an accelerated regulatory path after positive Phase I/II data; a pivotal BLA submission is anticipated in the second half of 2025. An IND was cleared for ST‑503 in iSFN pain with first patient dosing expected mid‑2025. Nonclinical proof-of-concept was demonstrated in prion disease models.[6][8]
- Therapeutic areas
- HematologyRare DiseasesNeurology
- Modalities
- Gene therapy (AAV-based gene transfer)Genome editing (Zinc Finger Nucleases - ZFN)Epigenetic regulation (Zinc Finger Protein Transcription Factors - ZFP-TF)
- Industry
- Biotech
02
Drug pipeline
34 assets33 more assets in the full pipeline.
03
Partnerships
Genentech/Roche – global epigenetic regulation & capsid delivery license agreement for neurodegenerative diseases[6]Astellas – capsid license agreement targeting up to five neurological indications[6]Previous or ongoing collaborations have included Pfizer, Biogen, Kite/Gilead, Lilly, Alexion, Takeda.[5][10]
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