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Seaport Therapeutics is advancing oral prodrugs via the Glyph platform for neuropsychiatric disorders. Lead candidate SPT-300 (GlyphAllo, allopregnanolone prodrug) is entering Phase 2b for major depressive disorder; SPT-320 (GlyphAgo, agomelatine prodrug) entering Phase 1 for generalized anxiety disorder; SPT-348 (Glyph 2BLSD) in preclinical for mood/neuropsychiatric disorders.
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