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Seaside Therapeutics

Cambridge, Massachusetts, United Statesorpha.net ↗
Ownership
Private
Development stage
Phase 3
01

Overview

Seaside Therapeutics was a biotech company focused on developing novel therapeutics for neurodevelopmental disorders such as fragile X syndrome and autism. Its lead candidate, STX209, an oral selective GABA-B receptor agonist, completed the largest randomized controlled Phase II trial in fragile X syndrome and an open-label Phase IIa trial in autism. Two Phase III studies for fragile X were enrolling at the time of its last major update. The company also had pending programs targeting mGluR5 and parathyroid hormone pathways. It entered a landmark partnership with Roche to advance late-stage development but ultimately went out of business.

Therapeutic areas
EndocrinologyPsychiatryNeurology
Modalities
Small moleculesGABA-B receptor agonists (e.g., STX209)mGluR5 modulators (e.g., STX107, STX110)Parathyroid hormone replacements (ST-1891)
Industry
Biotech
02

Drug pipeline

1 asset

arbaclofen

Phase 3
Indications
Fragile X syndrome, Autism spectrum disorder
03

Partnerships

Roche – strategic alliance to co-develop treatments for autism and fragile X syndrome including late-stage development support for STX209.

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