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Senz Oncology is advancing EO1001 (APL-122), a first-in-class oral irreversible pan-ErbB inhibitor with promising CNS penetration, in a Phase 1-2 clinical trial for ErbB-positive cancers including patients with CNS involvement.[3] The company previously initiated a Phase 1-2 trial of VAL-1000 in acute leukemias, which was later withdrawn.[3]
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