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Shape Theranostics
Seattle, Washington, United States
- Ownership
- Private
- Development stage
- Other
01
Overview
Shape Therapeutics is a private, preclinical-stage biotech developing AI-designed, programmable RNA medicines using its RNAfix RNA-editing payloads, AAV.ai brain-targeted delivery capsids, and TruStable AAV manufacturing platform. It has demonstrated robust preclinical CNS RNA editing (up to ~88% editing in non-human primate brain and durable editing in mouse brain models), as well as strong AAV manufacturing gains, but has not yet entered human clinical trials.[1][3][6][7]
- Therapeutic areas
- NeurologyOphthalmologyRare Diseases
- Modalities
- RNA therapytRNAAAV based gene therapyGene therapyNanoparticle
- Industry
- Biotech
02
Partnerships
Roche – collaboration using RNAfix and AAVid/AAV.ai platforms to develop next-generation tissue-specific AAV gene therapies for neurological and other indications[5]Otsuka – collaboration to develop AAV gene therapies for ocular diseases, leveraging Shape’s RNA editing and AAV platforms[5]VectorY Therapeutics – agreement to evaluate SHP-DB1 AAV capsid for delivery of VectorY’s Huntington’s and Alzheimer’s disease programs to the brain[5]
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