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Shuttlewagon
Gaithersburg, Maryland, USAshuttlewagon.com ↗
- Ownership
- Private
- Development stage
- Commercial
01
Overview
Shuttle Pharmaceuticals develops novel therapies designed to increase cancer cure rates by enhancing the effectiveness of radiation therapy while minimizing side effects. Its lead product, Ropidoxuridine, an oral halogenated pyrimidine with strong radiosensitizing properties, has advanced into Phase 2 clinical trials targeting glioblastoma. The pipeline also includes selective HDAC inhibitors in preclinical development as well as diagnostic tools such as predictive biomarkers for prostate cancer patients considering elective radiation therapy. Recent efforts include developing PSMA-targeted ligands and PARP inhibitor conjugates through academic collaborations.
- Therapeutic areas
- Oncology
- Modalities
- Small molecule (e.g., Ropidoxuridine)Histone deacetylase inhibitor (HDAC inhibitor)Ligand-drug conjugate (PSMA-targeted PARP inhibitor conjugates)
- Industry
- Biotech
02
Partnerships
Theradex Oncology (CRO partner)TCG GreenChem Inc. (manufacturing partner)UCSF sponsored research agreement on PSMA ligandscollaboration with Dr. Alan Kozikowski on PARP inhibitors
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