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Signal12 Inc.

Greenwich, Connecticut, USAsignal12inc.com ↗

Ownership: Private
Development stage: Phase 3

Overview

Signal12’s lead program, Pro‑ocular™, is a first-in-class, drop-free topical gel that targets the ophthalmic branch of the trigeminal nerve via transappendageal delivery. In three completed Phase 2 studies—including in oGvHD and Sjögren’s syndrome—Pro‑ocular™ demonstrated statistically significant improvements in both signs and symptoms of disease, with benefits maintained over a two-year extension. The company has secured FDA alignment on its pivotal Phase 3 trial design for oGvHD and is actively raising capital to advance development.

Therapeutic areas: ImmunologyOphthalmology
Modalities: Topical gel via transappendageal forehead delivery
Industry: Biotech

Drug pipeline

1 asset

Pro-ocular

Partnerships

Spencer Trask & Co.

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