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Silencio

London, United Kingdomsilencio.network ↗

Ownership: Private
Employees: ~115
Development stage: Commercial

Overview

Silence Therapeutics is a clinical-stage biotech company pioneering siRNA-based therapies using its mRNAi GOLD™ platform. Its lead assets include zerlasiran for cardiovascular risk reduction in patients with high lipoprotein(a), which has shown up to 99% reduction in Lp(a) levels in early studies, and divesiran for polycythemia vera, now enrolling Phase 2. The company also has additional candidates targeting hematological and complement-mediated diseases. Partnerships include AstraZeneca and previous collaborations with Hansoh Pharma. The company remains independent, publicly traded on Nasdaq, and active as of mid-2025.

Therapeutic areas: OncologyCardiovascularImmunologyHematology
Modalities: Small interfering RNARNA therapySynthetic oligonucleotide
Industry: Biotech

Partnerships

AstraZeneca (siRNA therapeutics collaboration)Mallinckrodt Pharmaceuticals (previous)Hansoh Pharma (previously active but now ended)

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