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Simmaron Research
Incline Village, Nevada, United States
- Ownership
- Private
- Development stage
- Other
01
Overview
Simmaron Research is running a biomarker-driven, multicenter pilot clinical trial repurposing low-dose rapamycin (an mTOR inhibitor) for ME/CFS, Long Covid and related infection-associated chronic conditions, with early data from ~80 participants indicating significant reductions in fatigue, post-exertional malaise, orthostatic intolerance and sleep disturbance in a biomarker-defined subset of patients, while concurrently validating blood-based autophagy biomarkers such as phosphorylated ATG13 for patient stratification.[1][4][5][9]
- Therapeutic areas
- CardiovascularImmunologyNeurologyInfectious Diseases
- Modalities
- Small moleculeNon-pharmacological therapy
- Industry
- Academic Hospital/University/Research
02
Partnerships
University of Wisconsin-MilwaukeeMilwaukee Institute for Drug DiscoveryColumbia UniversityCornell UniversityStanford UniversityCenters for Disease Control and PreventionNational Institutes of HealthMayo ClinicBateman Horne CenterCenter for Complex DiseasesThermo Fisher ScientificCoppe LaboratoriesIndiana University Health ICBISolve M.E.
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