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Before its 2008 acquisition by GlaxoSmithKline, Sirtris Pharmaceuticals was developing orally available small‑molecule activators of sirtuins, especially SIRT1, aiming to mimic calorie restriction for type 2 diabetes and other age‑related metabolic diseases; its lead programs (including resveratrol analogues such as SRT1460, SRT2104 and SRT2172) had reached preclinical and early clinical evaluation but did not advance to late‑stage development and were later reported to have significant assay and efficacy concerns.[5][4][9]
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