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Sirtris Pharmaceuticals

Cambridge, Massachusetts, United States
Ownership
Private
Development stage
Other
01

Overview

Before its 2008 acquisition by GlaxoSmithKline, Sirtris Pharmaceuticals was developing orally available small‑molecule activators of sirtuins, especially SIRT1, aiming to mimic calorie restriction for type 2 diabetes and other age‑related metabolic diseases; its lead programs (including resveratrol analogues such as SRT1460, SRT2104 and SRT2172) had reached preclinical and early clinical evaluation but did not advance to late‑stage development and were later reported to have significant assay and efficacy concerns.[5][4][9]

Therapeutic areas
ImmunologyEndocrinologyNeurologyPulmonologyMetabolic DisordersOncology
Modalities
Small molecule
Industry
Biotech
02

Partnerships

GSK (strategic integration as an autonomous drug discovery unit after acquisition)[5][3]

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