SMRSTope

SMRSTope is a biotechnology company headquartered in Shanghai, China, specializing in the discovery and development of therapeutic antibodies against challenging membrane protein targets. The company utilizes its proprietary SMRS-TOPE (Single-Molecule Recognition Signal - Topographic Epitope) platform, which integrates structural biology with high-throughput single-molecule imaging to identify unique conformational epitopes on complex proteins such as G protein-coupled receptors (GPCRs) and ion channels. This approach allows for the generation of highly specific antibodies that can modulate protein function in their native membrane environment. SMRSTope focuses its internal pipeline on high-value targets in oncology, immunology, and metabolic disorders. By overcoming the limitations of traditional antibody discovery methods for multi-pass transmembrane proteins, the company aims to address significant unmet medical needs in global healthcare.