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Stealth BioTherapeutics has demonstrated protective effects on photoreceptor loss in Phase 2 trials of elamipretide for dry AMD. Bevemipretide, a next-generation topical candidate, has shown promising preclinical results in models of dry AMD and glaucoma. Elamipretide is under review for Barth syndrome and late-stage development for primary mitochondrial myopathy. The pipeline includes additional compounds targeting rare neurological, cardiac, and muscle diseases associated with mitochondrial dysfunction.[2][3][4]
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