Structure Based Design

Structure Based Design is a private San Diego-based biotech and contract research company focused on structure-based drug discovery services for pharmaceutical, biotechnology, and academic clients. The company specializes in recombinant protein production, protein structure determination, macromolecule X-ray crystallography, fragment-based crystallographic screening, assay development, and gene-to-lead discovery support. Its business model appears to center on enabling client programs rather than advancing a large disclosed proprietary therapeutic pipeline. Structure Based Design also highlights capabilities in kinase, GPCR, and antibody discovery and has supported discovery programs such as tomivosertib through structural biology and crystallography. The company presents itself as an embedded scientific partner intended to accelerate hit identification and lead optimization.