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Stylus Systems
Cambridge, Massachusetts, United Stateske.linkedin.com ↗
- Ownership
- Private
- Employees
- ~40
- Development stage
- Other
01
Overview
Stylus Medicine is developing a next-generation in vivo genetic medicines platform using engineered recombinases delivered by cell-targeted lipid nanoparticles. Their lead programs are preclinical, with initial data from a single-dose trial of a CD3-targeted LNP delivering both recombinase and CAR constructs expected at the American Society of Gene & Cell Therapy meeting in May 2025. The approach aims to enable durable, precise genome integration for scalable in vivo CAR-T therapies that could overcome the limitations of ex vivo manufacturing and viral vectors.
- Therapeutic areas
- OncologyRare DiseasesImmunology
- Modalities
- Recombinase-based gene editingLipid nanoparticle delivery therapyCell therapy (in vivo CAR-T)Gene therapy (non-viral)
- Industry
- Biotech
02
Partnerships
Chugai Venture FundEli Lilly and CompanyJohnson & Johnson Innovation – JJDC
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