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Synereca developed small molecules to restore or increase the effectiveness of existing antibiotics against multidrug-resistant Gram-negative bacteria. Their lead program focused on compounds that potentiate Colistin without increasing toxicity and demonstrated significant in vitro and in vivo efficacy in preclinical models. Another program targeted RecA inhibition to block bacterial DNA repair and resistance development. No recent clinical results are available; company appears inactive since mid-late 2010s.
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