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TcL Pharma was a French biotechnology company specializing in the development of innovative immunotherapies for organ transplantation and autoimmune diseases. The company's core technology focused on the CD28/B7 molecular pathway to induce immune tolerance without the need for long-term immunosuppression. Its lead candidate, FR104, is a pegylated monoclonal antibody fragment (Fab') designed to selectively block CD28. TcL Pharma merged with Effimune in 2013, which subsequently merged with OSE Pharma in 2016 to form OSE Immunotherapeutics. The company's legacy continues through the ongoing development of its CD28 antagonist programs within OSE Immunotherapeutics.
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