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Tenet Medicines was a development-stage biotechnology company focused on advancing therapies for autoimmune and inflammatory diseases. The company's lead asset, TNT001 (now LY3845087), is a potent, clinical-stage monoclonal antibody targeting CD19, designed to deplete B cells for the treatment of systemic lupus erythematosus and other B-cell mediated conditions. Tenet was founded by industry veterans with the goal of optimizing B-cell depletion strategies to provide better outcomes for patients with refractory autoimmune disorders. In April 2024, the company was acquired by Eli Lilly and Company to bolster Lilly's immunology pipeline.
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