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Threshold Pharmaceuticals

South San Francisco, California, United States

Ownership: Private
Development stage: Other

Overview

Threshold conducted multiple Phase 3 clinical trials for TH-302 (evofosfamide) in combination with doxorubicin for soft tissue sarcoma and with gemcitabine for pancreatic cancer under Special Protocol Assessment agreements with the FDA. The company also developed tarloxotinib for EGFR-positive cancers in Phase 2 trials. Primary analysis of the soft tissue sarcoma Phase 3 trial was anticipated in Q1 2016, with pancreatic cancer trial events expected in second half of 2015.

Therapeutic areas: Oncology
Modalities: Small moleculeHypoxia-activated prodrug
Industry: Biotech

Partnerships

Merck KGaA (Darmstadt, Germany) - global license and co-development agreement for TH-302/evofosfamide with option for Threshold to co-commercialize in U.S.Sarcoma Alliance for Research through Collaboration (SARC) - partnership for Phase 3 soft tissue sarcoma trialUniversity of Texas MD Anderson Cancer Center - Phase 1 immunotherapy clinical trialUniversity of Auckland, New Zealand - exclusive worldwide license for tarloxotinib

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