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TigaTx

Boston, MA, United Statestigatx.com ↗

Ownership: Private
Development stage: Preclinical

Overview

TigaTx has developed a proprietary platform for engineering monomeric and dimeric IgA antibodies that engage neutrophils as anti-tumor effectors. The lead program, an anti-EGFR IgA antibody (TIGA‑001), is advancing toward clinical trials with support from ARPA-H and NIH funding. The company’s approach aims to address resistance seen with current anti-EGFR therapies and expand into infectious disease indications using secretory/dimeric IgA. In April 2025, TigaTx was acquired by Epsilogen, becoming its subsidiary and contributing its pipeline and technology to create a pan-isotype antibody company[2][3][6].

Therapeutic areas: OncologyInfectious Diseases
Modalities: Engineered monoclonal antibodies (IgA)Neutrophil engagersSecretory/dimeric IgA (for infectious diseases)
Industry: Biotech

Drug pipeline

1 asset

TIGA-001

Pre-clinical

Indications: Colorectal cancer, Lung cancer, Head and neck cancer

Partnerships

ARPA-H/NIH funding partnershipsacademic collaborations with Weill Cornell Medicine, Yale University, Hadassah Hebrew University Medical Center[2]

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