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Toko Pharmaceutical Industrial has achieved commercial approval for several small molecule drugs, including dexamethasone propionate for eczema, indomethacin and methyl salicylate/l-menthol/dl-camphor for pain, and tamibarotene for acute promyelocytic leukemia. Tamibarotene is an improved synthetic retinoid with clinical evidence from Phase 2 studies showing a 60% complete response rate in relapsed APL patients in Japan. All drugs listed are approved and commercially available in Japan.[3][9]
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