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Tolero’s lead compound alvocidib, a CDK9 inhibitor licensed from Sanofi, demonstrated proof-of-concept in randomized Phase 2 studies for AML and received Orphan Drug Designation from both FDA and EMA. Additional assets include an oral prodrug version of alvocidib and other kinase inhibitors targeting oncology indications. The company was acquired by Sumitomo Dainippon Pharma for up to $780 million to strengthen its oncology pipeline.
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