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Topas Therapeutics

Hamburg, Germanytopas-therapeutics.com ↗

Ownership: Private
Employees: ~50
Development stage: Phase 2

Overview

Topas Therapeutics has demonstrated initial clinical proof of concept with its lead candidate TPM502 in a Phase 2a trial for celiac disease showing targeted antigen-specific tolerogenic effects. The persistence of these effects supports the platform’s potential across multiple autoimmune indications. TPM203, their lead program for pemphigus vulgaris, has completed Phase 1 with an excellent safety profile and moved into further clinical testing[1][4][8][10].

Therapeutic areas: GastroenterologyImmunology
Modalities: Antigen-specific nanoparticle conjugates (nanoparticle-based therapeutics)Immune tolerance-inducing biologic modality
Industry: Biotech

Drug pipeline

3 assets

TPM502

2 more assets in the full pipeline.

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Partnerships

Research and option agreement with Eli Lilly focused on antigen-specific tolerance induction.Multi-year collaboration agreement with Boehringer Ingelheim on anti-drug antibodies.Co-development agreement with Evotec for a Type I diabetes program currently preclinical[6].

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